It works by helping the blood flow into the penis to achieve and maintain an erection. The injectable form causes an erection firm enough for sex in more than 80% of men with erectile dysfunction regardless of their age or the cause of their ED. The name MUSE is an acronym for Medicated Urethral System for Erection. It is very important that MUSE not be exposed to temperatures above 30C/86F since this will make MUSE ineffective. What is this medicine? . Alprostadil is also used to improve blood flow in . You should not use MUSE if you have any of the following: WHAT ARE THE POSSIBLE SIDE EFFECTS OF MUSE? ALPROSTADIL (al PROS ta dil) is a natural protein. This fast-acting erectile dysfunction treatment can give you an erection from 10 minutes after taking it. Selected from data included with permission and copyrighted by First Databank, Inc. MUSE is supplied in individual foil pouches containing one (1) system per pouch. Viagra is usually the preferred first treatment option for men with impotence. The inactive ingredient in MUSE is polyethylene glycol 1450, USP. Prostaglandin E1 is a naturally occurring acidic lipid that is synthesized from fatty acid precursors by most mammalian tissues and has a variety of pharmacologic effects. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Throw out the needles. Or you can use it as suppository, placing it into the opening at the tip of the penis. MUSE should be administered as needed to achieve an erection. Alprostadil is a sort of drug that reasons veins to unfold, expanding blood stream all through the figure. What conditions does Alprostadil Suppository treat. This increases blood flow to the penis and will enhance your erection. If symptoms persist, call your doctor promptly. If you keep it in your fridge, dont let it freeze. This site complies with the HONcode standard for trustworthy health information: verify here. Call your doctor immediately if you have any of these rarer problems: Do supplements, herbal remedies, and more work? First, urinate. The majority of DHK-PGE1 is further metabolized to smaller prostaglandin remnants that are cleared primarily by the kidney and liver. Copyright 2022 IBM Watson Health. Every vial ordered is approximately 8 doses and comes complete with instructions and syringes. See what others have said about Alprostadil (Muse), including the effectiveness, ease of use and side effects. Each MUSE is for single use only and should be properly discarded after use. MUSE may be kept at room temperature (less than 30C/86F) for up to 14 days prior to use. Muse (Alprostadil), 250mcg, Suppositories, 6/Box. MUSE is intended for single-dose application only. HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start using alprostadil and each time you get a refill. Please read this pamphlet before using MUSE (alprostadil). Between 60% and 90% of PGE1 has been shown to be metabolized after 1 pass through the pulmonary capillary beds. The use of a water-based lubricant may help prevent vaginal irritation. Injectable alprostadil is sold under the brand names Caverject, Edex, and Prostin VR. Also, your erection may continue after orgasm. It is used to treat neonates with a specific heart defect. This pamphlet is a quick reference source on important information about MUSE for you and your partner. This medicine helps to create and maintain an erection. ALPROSTADIL SUPPOSITORY - PENILE. It works by helping the blood flow into the penis to achieve and maintain an erection. To decrease your risk of infection, always use an effective barrier method such as a latex or polyurethane condom during all sexual activity. The active compound in intraurethral MUSE is alprostadil, a prescription medication that expands blood vessels and increases blood flow in the body, . Doctors dont know if alprostadil will affect the baby. Alprostadil injection and suppositories are used to treat certain types of erectile dysfunction (impotence; inability to get or keep an erection) in men. Erectile dysfunction (sometimes called impotence) means that you cannot get or maintain a proper erection. It may be given to you for other reasons. Wash your hands before and after use. Start by urinating. There are 4 dose strengths available: 125, 250, 500, and 1000 micrograms. You can get alprostadil injected directly into the penis. Do not expose to direct sunlight. Alprostadil is the active ingredient of this treatment for erectile dysfunction and its function is to widen the blood vessels in the penis by relaxing the thin layer of muscle of the vessel wall. This medicine usually begins to work in about 5 to 10 minutes. An effective dose of MUSE should produce an erection sufficient for sexual intercourse. If you have any questions about how to use this medication, ask your doctor or pharmacist. In female partners, vaginal burning/itching may occur. A very serious allergic reaction to this drug is rare. Distributed by: information submitted for this request. These materials provide visual instruction and more detailed information as well as practical tips on how to use MUSE. This allows more blood to flow to your penis to encourage an erection. An erection should begin within 5 10 minutes after administering MUSE. If symptoms persist, call your doctor promptly. The duration of effect is approximately 30-60 minutes. It belongs to a group of medicines called vasodilators that can increase blood flow by expanding blood vessels. Alprostadil (Muse) received an overall rating of 9 out of 10 stars from 4 reviews. Do not store in the trunk of a car or in baggage storage areas where MUSE may be exposed to extremes in temperature. Do not reuse them! If used, ice packs should be applied alternately to each inner thigh for a period not exceeding 10 minutes. MUSE may not create an erection such as those you experienced when you were younger. Policy, Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Visitation, mask requirements and COVID-19 information. The duration of effect is approximately 30 60 minutes. Syncope (fainting) was reported by 0.4% of patients. Alprostadil urethral suppository May 06, 2021 . Talk to your health care provider about the use of this medicine in children. Do not expose to temperatures above 30 degrees C (86 degrees F). MUSE alprostadil is a vasodilator that you administer directly to your penis as a urethral suppository. That boosts blood flow throughout the body, including the penis, so it helps men with ED have an erection. Alprostadil is in a class of medications called vasodilators. Patients often incorrectly use the product called medicated urethral suppository for erection (MUSE), a urethral alprostadil suppository prescribed for erectile dysfunction. Alprostadil is a form of prostaglandin, a hormone that naturally occurs in the body, and works by relaxing the smooth muscle in the arteries, increasing blood flow. ADDITIONAL INFORMATION AND PRACTICAL TIPS. Urethral suppository: If your sex partner is able to get pregnant, use birth control that you can trust to prevent pregnancy. After you have administered MUSE, replace the cover on the applicator, place in the opened foil pouch, fold, and discard as normal household waste. The suppository version is called MUSE (also referred to as Transurethral therapy) and . Alprostadil injection is also sometimes used in combination with other tests to diagnose erectile dysfunction. After administration, the erection process will begin within 5 10 minutes, and may last 30 60 minutes. If the medicine is not used properly, permanent damage to the penis and loss of the ability to have erections could result. If you experience dizziness or feel faint during sexual intercourse, this may be due to low blood pressure. Although unreported in clinical trials, there is the possibility that an overdosage of MUSE can cause priapism, a painful erection of the penis sustained for hours and unrelieved by sexual intercourse or masturbation. When traveling, store MUSE in a portable ice pack or cooler. Canada residents can call a provincial poison control center. Alprostadil is suspended in polyethylene glycol 1450 (as excipient) and is formed into a medicated pellet (micro-suppository measuring 1.4 mm in diameter by 3 mm or 6 mm in length) that resides in the tip of a translucent hollow applicator. information is beneficial, we may combine your email and website usage information with Patients who experience a prolonged erection should seek prompt medical attention. Wipe the tops of the injection bottles with an alcohol swab. If you do experience dizziness or feel faint, this may be due to the lowering of your blood pressure. WHAT ARE THE POSSIBLE SIDE EFFECTS OF MUSE FOR YOUR PARTNER? Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. The near-complete pulmonary first-pass metabolism of PGE1 is the primary factor influencing the systemic pharmacokinetics of MUSE and is a reason that peripheral venous plasma levels of PGE1 are low or undetectable (< 2 picograms/mL) following MUSE administration. MUSE is not indicated for use in newborns, children, or women. This medication is used by inserting the suppository into the penis as directed by your . (See also: WHAT ARE THE POSSIBLE SIDE EFFECTS OF MUSE? on the other side.). This medication is used by inserting the suppository into the penis as directed by your doctor. health information, we will treat all of that information as protected health MUSE is administered by inserting the applicator stem into the urethra after urination. The most common side effect is pain in the area where you get the shot. Alprostadil injection should not be used as a sexual aid by men who do not have ED. Cleveland Clinic is a non-profit academic medical center. This product is available in the following dosage forms: There is a problem with Sit, stand, or walk for 10 minutes to boost blood flow to your penis to help with an erection. Advertising revenue supports our not-for-profit mission. Initial absorption is rapid, with approximately 80% of an administered dose absorbed within 10 minutes. We have been in business since 2009 and have the lowest prices worldwide. Before using this medicine, consult your doctor or pharmacist if you have: genito-urinary tract disorder (such as urethral stricture/obstruction, urethritis, inflammation/infection of the head of the penis), indwelling urethral catheter. If its not used properly, it can permanently damage the penis. Intraurethral alprostadil (Vivus's MUSE) is an intraurethral medication (i.e., a drug that is injected into the urethra) that was approved by the FDA in June 1998. To obtain prescription medications, Prescription Hope works directly with over 180 pharmaceutical manufacturers and their pharmacy to obtain Caverject at a set . The mean total endogenous PGE content (PGE1, PGE2, 19-OH-PGE1, and 19-OH-PGE2) of the ejaculate in these subjects was 444 mcg (range 0-1423 mcg). The vasodilatory effects of alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arterial inflow and expansion of the lacunar spaces within the corpora. Price and Cost information of Alprostadil brand and generic drugs. MUSE and MEDA PHARMACEUTICALS are registered trademarks, and theMEDA PHARMACEUTICALS logo is a trademark of Meda AB or a related entity. Please read patient instruction leaflet regarding usage and storage. Do not use MUSE more than twice in a 24-hour period. Its solubility at 35C is 8000 mcg per 100 mL double-distilled water. After you mix a single dose, you must use it immediately. The new formulation of alprostadil in a suppository form (MUSE, Vivus) offers men an alternative to injection therapy for erectile dysfunction. You may report side effects to Health Canada at 1-866-234-2345. The injectable form is available in 10, 20, and 40mcg . But this is not the shot, it is the urethral suppository. For Alprostadil Suppositories. If any of the information is unclear, consult your doctor or pharmacist. 5 Stars. How to use Alprostadil Suppository Read the Patient Information Leaflet provided by your pharmacistbefore you start using alprostadiland each time you get a refill. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Reviewed: June 23, 2020. Controlled: This product requires a verified medical license to purchase. This helps to increase the flow of blood into the penis, which then leads to an erection. Wait 10-30 minutes before you have sex. By expanding blood stream to the penis, alprostadil assists speed up an erection. Most of the side effects reported in men are relatively minor and include burning and aching in the penis and groin. The lower doses of MUSE (125 mcg or 250 mcg) are recommended for initial dosing. The most frequently reported drug-related side effects during in-clinic titration included pain in the penis (36%), urethra (13%), or testes (5%). About 80% of alprostadil administered by MUSE is absorbed within 10 minutes and is rapidly cleared from the systemic circulation by the lungs, leaving barely detectable systemic blood levels. When used via a suppository, it works the same way as when it is injected. - PLEASE NOTE: AFTER USING MUSE, YOU SHOULD AVOID ACTIVITIES, SUCH AS DRIVING OR HAZARDOUS TASKS, WHERE INJURY COULD RESULT IF DIZZINESS OR FAINTING WERE TO OCCUR. The suppository is about half the size of a grain of rice. The half-life of alprostadil in humans is short, varying between 30 seconds and 10 minutes, depending on the body compartment in which it is measured and the physiological status of the subject. Intravenous doses of 1 to 10 micrograms per kilogram of body weight lower blood pressure in mammals by decreasing peripheral resistance. You can use a small amount of lubricant like KY jelly or Astroglide to . brand suppository 1000mcg 6 suppositories Advertisement Free Coupons Prices as low as $472.26 Savings Clubs Prices as low as $483.76 Mail Order Prices as low as $3,198 Set your location for drug prices near you Popular Walmart $562 retail Save 11% $497.03 with free Discount Get free Discount Walgreens $588 retail Save 15% $495.43 with free Coupon MUSE (Alprostadil) is indicated for the treatment of erectile dysfunction. Alprostadil reaches its peak levels within minutes and successful erection is achieved within 5 to 10 minutes. Talk with the doctor. Intravaginal administration of up to 4000 mcg/day of MUSE (alprostadil) to pregnant rabbits (1100 mcg/kg/day or about 12.5 times the maximum recommended daily dose adjusted for body surface area) resulted in no evidence of harm to the fetus. Please note: This is a refrigerated product, and it can only be shipped using our EMS courier option. Men should inform their doctors if they wish to father a child. The MUSE system was evaluated in 7 placebo-controlled trials of various design in over 2500 patients with a history of erectile dysfunction of various etiologies. You may opt-out of email communications at any time by clicking on This medicine helps to create and maintain an erection. The new formulation of alprostadil in a suppository form (MUSE, Vivus) offers men an alternative to injection therapy for erectile dysfunction. Call your doctor if you suspect you may require a dosing adjustment. The latter dose produced maternal toxicity (ataxia, lethargy, diarrhea, and retarded body weight gain). The MUSE applicator (Fig.1) contained in each foil pouch is intended for 1 administration only. Very effective for patients who are experiencing erectile dysfunction secondary to radical prostatectomy. 996 patients (66% of those who began titration) were studied during the home treatment portion of 2 Phase III placebo-controlled studies. Select a condition to view a list of medication options. Dont store it -- you cannot use it later on. Alprostadil should not be used as a sexual aid by men who do not have erectile dysfunction. This medicine is available only with your doctor's prescription. In vitro, alprostadil (PGE1) has been shown to cause dose-dependent smooth muscle relaxation in isolated corpus cavernosum and corpus spongiosum preparations. alprostadil 1000 MCG Urethral Suppository is also used to improve blood flow in newborn babies with a certain genetic heart condition. Because MUSE has not been tested during human pregnancy, it is recommended that couples use adequate contraception if the female partner is of childbearing potential. urethral suppository. Before using this product, tell your doctor or pharmacist of all the products you use. Save on Alprostadil at your pharmacy with the free discount below. Limit alcoholic beverages. Of note, the needle used for administration of alprostadil solution is a superfine (27- to 30-gauge) needle; with such a fine needle, breakage is possible. The chemical name for alprostadil is prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-(11,13E,15S)-(1R,2R,3R)-3-hydroxy-2-[(E)-(3S)-3-hydroxy-1-octenyl]-5-oxo-cyclopentane heptanoic acid, and the molecular weight is 354.49. Human semen contains PGE1, but additional amounts may be present from MUSE administration (see CLINICAL PHARMACOLOGY). It is recommended that you use a condom during sexual intercourse. Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. Call your doctor for medical advice about side effects. Alprostadil is rapidly metabolized locally by enzymatic oxidation of the 15-hydroxyl group to 15-keto-PGE1. Do not use more often than directed. If we combine this information with your protected alprostadil intracavernous/urethral increases effects of antithrombin alfa by pharmacodynamic synergism. Its solubility at 35C is 8000 micrograms per 100 mL double distilled water. masters in marketing south korea. It is based on the discovery that the urethra (the normal pathway for urine) can absorb certain medications into the surrounding erectile tissues thereby creating an erection. MUSE works differently than sildenafil ( Viagra ), the . This will reduce blood flow to the penis and may reduce the erection. What are the side effects associated with MUSE? Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. MUSE is a registered trademark of Meda AB, a Mylan company. Muse (alprostadil) is a prostaglandin. 996 patients (66%) completed dose titration, achieved an erection sufficient for intercourse, and were randomized equally to placebo or active treatment and followed during at-home treatment for up to 3 months. Alprostadil is a white to off-white crystalline powder with a melting point between 110 and 116C. Urinating prior to administration will reduce the chance of discomfort or abrasions and is important for dissolving the medicated pellet. Fewer than 2% of patients discontinued from these studies primarily because of adverse events. You may report side effects to FDA at 1-800-FDA-1088. Alprostadil (suppository) is a endocrine-metabolic agent , erectile dysfunction agent and genitourinary agent that is FDA approved for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology. It is used to treat erectile dysfunction (ED). An application of ice packs to the inner thigh may shorten the duration of the erection, since the cold will restrict blood flow to the penis. Alprostadil. If this drug is used by a male for sexual intercourse with a pregnant woman, an effective barrier method such as a latex or polyurethane condom should be used. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Following MUSE administration, alprostadil is absorbed from the urethral mucosa into the corpus spongiosum. It works by relaxing the blood vessels and muscles in the penis. The chemical name for Alprostadil is (1R,2R,3R)-3-Hydroxy-2- [ (E)- (3S)-3-hydroxy-1-octenyl]-5-oxocyclopentane heptanoic acid, and the molecular weight is 354.49. Reflex increases in cardiac output and heart rate may accompany these effects. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. ALPROSTADIL (al PROS ta dil) is a natural protein. USES: This medication is used to treat male sexual function problems (erectile dysfunction). Congrats on making your first step in finding and choosing the ultimate erectile erectile dysfunction solution with Alprostadil- (Caverject)! (al-PROS-ta-dil) COMMON BRAND NAME (S): Muse. Only 50 patients (4.3%) discontinued treatment because of a TRAE, and only four (0.3%) discontinuations were due to the partner. Portfolio. This medicine is not for regular use. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Seniors Taking Multiple Meds: Its a Complicated Problem, 3 COVID Scenarios That Could Spell Trouble for the Fall, Colonoscopy Benefits Lower Than Expected (Study), Dr. Whyte's Book: Take Control of Your Diabetes Risk, Street Medicine Reaches People Where They Live, Health News and Information, Delivered to Your Inbox, Healthy Sex Life: Better Health Evaluator from WebMD, If you are allergic to any other substances such as drugs, foods, preservatives, or dyes, If you take any prescription or over-the-counter drugs including herbal and, Problems with your penis, such as curvature or birth defects, Conditions that cause thickened or slower blood flow such as, Curving of the penis with pain during an erection, Erection lasts for 4 to 6 hours with severe and continuing pain in the penis. This list may not describe all possible interactions. This drug may make you dizzy. This medicine causes an erection because it increases the blood flow to the penis. Do not store in the trunk of a car or in baggage storage areas. MUSE represents a unique approach for the treatment of erectile dysfunction, commonly called impotence. After my erection is over, will my penis feel sensitive? Learn all usage instructions in the product package. Before using this medication, tell your doctor or pharmacist your medical history, especially of: penis conditions (such as angulation, cavernosal fibrosis, Peyronie's disease), bleeding disorders, blood system cancers (such as leukemia, multiple myeloma), heart disease, low blood pressure, sickle cell anemia. You can use a small amount of lubricant like KY Jelly or Astroglide to help you insert the applicator. For instance, keep it out of warm, moist settings (such as the bathroom). Similarly, an erection that lasts longer than desired may require a dose decrease. Get rid of any unused medicine after 14 days. Priapism can result in permanent worsening of erectile function. Note: Call your doctor promptly if you have a rigid erection that lasts more than 4 hours. The enzyme catalyzing this process has been isolated from many tissues in the lower genitourinary tract including the urethra, prostate, and corpus cavernosum. You and your physician will determine the appropriate dose of MUSE. ALPROSTADIL (al PROS ta dil) is used to treat erectile dysfunction (ED). All rights reserved. Erectile dysfunction is the inability to attain or maintain an erection sufficient for sexual intercourse. Medical information line at Meda Pharmaceuticals Inc. 1-888-345-MUSE (1-888-345-6873). Choosing between the injection and suppository is a personal choice. Nearly all of the alprostadil entering the central venous circulation is removed in a single pass through the lungs; thus peripheral venous plasma levels of PGE1 are low or undetectable (< 2 picograms/mL) after MUSE administration. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. It relaxes the blood vessels and muscles in your penis. The following table summarizes the frequency of adverse events reported by patients using MUSE or placebo. MUSE is an acronym of Medicated Urethral Suppository for Erection and is classed as a medicated pellet and is administered using a plastic applicator. This medicine causes an erection because it increases the blood flow to the penis. The active ingredient in MUSE is alprostadil, which is chemically identical to the naturally occurring eicosanoid, prostaglandin E1 (PGE1). Overdosage has not been reported with MUSE. During post-marketing surveillance syncope occurring within one hour of administration has been reported. How do I know if I have the correct dose of MUSE? Keep unopened medicine in the pouch. Please read patient instruction leaflet . Uses of Alprostadil Urethral Suppository: It is used to treat erectile dysfunction (ED). To report side effects, contact Meda Pharmaceuticals Inc. at 1-888-367-6873 or contact FDA at 1-800-FDA-1088, fax 1-800-FDA-0178 or online at www.fda.gov/medwatch/report.htm. Before using alprostadil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Muse (Alprostadil), 250mcg, Suppositories, 6/Box $542.14 Item Code: 004812. To report side effects, contact Meda Pharmaceuticals Inc. at 1-888-367-6873 or contact FDA at 1-800-FDA-1088, fax 1-800-FDA-0178 or online at www.fda.gov/medwatch/report.htm. include protected health information. It is not clear if this side effect is caused by the medication or sexual intercourse itself. Contains PGE1, but having the man lie down and begin sexual activity you are ready to this. Carcinogenicity studies of alprostadil are alprostadil suppository, inhibition of platelet aggregation, and 1000 micrograms dose. A verified medical license to purchase PGE1 levels in the penis and groin: verify here the same as Directions on the effects of alprostadil in a refrigerator at 36-46 degrees F ) length when inserting the MUSE System. And include burning and aching in the ejaculate averaged 31 mcg ( range 0-161 mcg ) are recommended initial Open the cheeks in 4 dosage strengths: 125 mcg, 500 mcg, and more work,! Achieve and maintain an erection a registered trademark of Meda AB, a Mylan.. As passing out or trouble breathing, call a poison control center on your medical condition and response therapy. 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